Female Genital Tuberculosis: An Epidemiological study and development of a novel endometrium specific biomarker.
Principal Investigator: Dr Ramalingam Sankaran
Co-Investigators: Dr Thiagarajan Sairam
Dr Sudha Ramalingam
Dr Seetha Panicker
Dr T V Chithra
Tuberculosis is a major public health problem and female genital tuberculosis (FGTB) comprises of 10% of cases with pulmonary tuberculosis. However, there is a paucity of data in our state on Female genital tuberculosis and the invasive diagnostic procedures make early diagnosis complex. We aim to study the proportion of women who suffer from FGTB among those who present with secondary amennorheoa, infertility and Pelvic inflammatory diseases. The lab is also actively involved in validating a multiplex PCR for the diagnosis of FGTB and ultimately to develop a novel serum biomarker to diagnose the disease early.
Genotype-Phenotype Correlation of a novel G protein coupled Receptor Kinase 5 (GRK5) polymorphism in patients with Congestive Heart Failure –Implications in treatment
Principal Investigator: Dr Sudha Ramalingam
Co-Investigators: Dr Thiagarajan Sairam
Dr Ramalingam Sankaran
Dr J S Bhuvaneswaran
Dr G Rajendiran
The project aims to study the significance of the polymorphism GRK5Leu41 in G protein coupled receptor kinase protein 5 (GRK5) and its association with the therapeutic response to beta blocker in patients with cardiac failure. It also aims to study the potential of GRK5 as a biomarker for prognosis in patients with cardiac failure. The significance of BNP and ProBNP values will also be measured and will give an insight into its significance as a marker in prognosis of patients with cardiac failure.
Expression of Toll- like Receptor Signaling Pathway Genes in Rheumatoid Arthritis
Principal Investigator: Dr Thiagarajan Sairam
Co-Investigators: Dr Sudha Ramalingam
Dr Ramalingam Sankaran
Dr Dinakar Rai
Dr Sujaya Menon
Rheumatoid arthritis is a chronic debilitating inflammatory disease. Recent evidence links the important role of toll like receptors in the etiology of Rheumatoid arthritis. Our project aims to identify the polymorphisms in toll like receptor genes in patients with confirmed diagnosis of Rheumatoid arthritis. We are also aiming at looking at the expression patterns of adapter proteins in patients with rheumatoid arthritis and also to assess effects of TLR stimulation on proinflammatory cytokine production by peripheral blood mononuclear cells (PBMCs) from patients with recent-onset RA, , as compared to healthy controls.
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